ATP has quickly become one of my favourite podcasts. What's it about? As the name states, it's a tech podcast. It's fairly Apple-focused. There is a fair amount of talk about Macs and iOS devices and all the things that go along with that. The 3 guys doing all the talking are 3 very different characters, which makes the interaction great and provides varying viewpoints. It's probably a little too technical for a lot of people, but it's fun, and you'll learn some things. I have.
Basically, the Daring Fireball podcast.